研資局高級研究學者計劃 | 教資會及研資局獎項

Biography
(只提供英文版)

Professor in Department of Biomedical Engineering at The Hong Kong Polytechnic University
Research interests include understanding the underlying mechanisms and possible translational strategies of using ultrasound to modulate cellular activities, such as neuromodulation or immunotherapy, investigating the potentials of ultrasound bio-effects for cancer therapy and diabetes, and multimodality molecular imaging and theranostics
SRFS project — to develop a new version of sonogenetics specific for non-human primate (NHP) and investigate the performance in terms of cellular specificity, spatial accuracy, and penetration capability of this non-invasive method for modulating specific brain region of non-human primates. The success of this research will make a groundbreaking innovation to brain stimulation studies, adding a critical approach for brain stimulation with non-invasiveness, deep brain penetration, and precision. This strategy will open a new dimension for ultrasound brain stimulation to have a significant impact on public health related mental illness and neurological disorders, e.g. Parkinson’s disease, Alzheimer’s disease and depression. It may also become an enormously useful research tool in basic neuroscience.
Awards and Honours:
- RGC Senior Research Fellow (2025)

Project Title
(只提供英文版)

Development of Sonogenetics for Non-human Primates

讚詞

孫雷教授為香港理工大學生物醫學工程系教授，擁有超過二十年醫療超聲波技術研究與開發經驗。孫教授獲研究資助局「高級研究學者計劃」資助，領導為期五年的研究項目。該項目旨在開發專為非人類靈長類動物（Nonhuman Primates）而設的專屬「聲遺傳學」（Sonogenetics）技術，標誌著該技術邁向人體臨床應用的關鍵一步。

研究團隊將針對此非侵入性技術的三大核心指標，「細胞特異性（Cellular specificity）」、「空間精准度（Spatial accuracy）」及「深層組織穿透力（Deep-tissue penetration）」進行深入研究。透過開創這項技術，克服大腦複雜結構，並為腦刺激研究帶來了突破和創新。

此研究不僅為基礎神經科學提供了極具價值的研究工具，更為公共衛生領域開闢新維度，為柏金遜症、阿茲海默症及抑鬱症等神經與精神疾病，提供一個非侵入性且高精准度的治療選擇。