研资局高级研究学者计划 | 教资会及研资局奖项

Biography
(只提供英文版)

Professor in Department of Biomedical Engineering at The Hong Kong Polytechnic University
Research interests include understanding the underlying mechanisms and possible translational strategies of using ultrasound to modulate cellular activities, such as neuromodulation or immunotherapy, investigating the potentials of ultrasound bio-effects for cancer therapy and diabetes, and multimodality molecular imaging and theranostics
SRFS project — to develop a new version of sonogenetics specific for non-human primate (NHP) and investigate the performance in terms of cellular specificity, spatial accuracy, and penetration capability of this non-invasive method for modulating specific brain region of non-human primates. The success of this research will make a groundbreaking innovation to brain stimulation studies, adding a critical approach for brain stimulation with non-invasiveness, deep brain penetration, and precision. This strategy will open a new dimension for ultrasound brain stimulation to have a significant impact on public health related mental illness and neurological disorders, e.g. Parkinson’s disease, Alzheimer’s disease and depression. It may also become an enormously useful research tool in basic neuroscience.
Awards and Honours:
- RGC Senior Research Fellow (2025)

Project Title
(只提供英文版)

Development of Sonogenetics for Non-human Primates

赞词

孙雷教授为香港理工大学生物医学工程系教授，拥有超过二十年医疗超声波技术研究与开发经验。孙教授获研究资助局「高级研究学者计划」资助，领导为期五年的研究项目。该项目旨在开发专为非人类灵长类动物（Nonhuman Primates）而设的专属「声遗传学」（Sonogenetics）技术，标志着该技术迈向人体临床应用的关键一步。

研究团队将针对此非侵入性技术的三大核心指标，「细胞特异性（Cellular specificity）」、「空间精准度（Spatial accuracy）」及「深层组织穿透力（Deep-tissue penetration）」进行深入研究。透过开创这项技术，克服大脑复杂结构，并为脑刺激研究带来了突破和创新。

此研究不仅为基础神经科学提供了极具价值的研究工具，更为公共卫生领域开辟新维度，为柏金逊症、阿兹海默症及抑郁症等神经与精神疾病，提供一个非侵入性且高精准度的治疗选择。